Glycyrrhizin: What It Is and Why It Matters

Glycyrrhizin is the sweet compound that comes from licorice root. You probably know licorice candy, but the real power of glycyrrhizin lies in medicine and supplements. It’s used for its anti‑inflammatory and antiviral properties, and sometimes as a natural sweetener in foods.

If you’ve ever taken an herbal cough syrup or seen licorice‑flavored throat lozenges, chances are glycyrrhizin was part of the formula. That’s why understanding how it works can help you decide if it’s right for you.

Health Benefits and Everyday Uses

One of the biggest draws of glycyrrhizin is its ability to calm inflammation. Studies show it can ease sore throats, reduce skin irritation, and even help with mild liver issues. People also use it for digestive discomfort because it can soothe the stomach lining.

Because it’s naturally sweet, some food manufacturers add glycyrrhizin to replace sugar in low‑calorie products. It’s about five times sweeter than sucrose, so a little goes a long way. In traditional Chinese medicine, glycyrrhizin is combined with other herbs to balance hormones and support adrenal health.

For athletes, a small dose of glycyrrhizin may improve endurance by moderating cortisol spikes after intense workouts. However, the dose matters—a pinch can help, but too much can cause problems.

Safety Tips and Possible Side Effects

The biggest warning with glycyrrhizin is its impact on blood pressure. High doses can trap sodium and lose potassium, leading to hypertension and swelling. If you have a history of heart issues, talk to a doctor before adding licorice extracts to your routine.

Typical supplement doses range from 50 mg to 150 mg per day. Going above 500 mg consistently can raise blood pressure within a week. If you notice headaches, tiredness, or unusual swelling, stop using it and seek medical advice.

Pregnant or nursing women should be extra careful. While low amounts from food are generally safe, high‑strength supplements aren’t recommended without professional guidance.

To keep things safe, always read product labels. Look for “standardized glycyrrhizin” and avoid brands that list “licorice root extract” without specifying the glycyrrhizin content. Buying from reputable sources reduces the risk of contaminated or mislabeled products.

Bottom line: glycyrrhizin can be a useful natural aid for inflammation, soothing sore throats, and adding sweetness without sugar. Use it responsibly, stay within recommended doses, and check with a healthcare provider if you have chronic health conditions.

Need more help? Browse our articles on related topics like herbal supplements, safe online pharmacy purchases, and how to read medication labels. We’ve got practical tips to keep you informed and healthy.