FDA-Approved Medications You Can Flush Down the Toilet (And When to Do It)

Most people think flushing medicine down the toilet is bad - and they’re right. Flushing medications can pollute waterways, harm aquatic life, and contaminate drinking water. But there’s one important exception: a short list of drugs the FDA says you should flush only if no other safe disposal option exists. This isn’t a free pass. It’s a last-resort safety measure for medications that can kill a child or pet with a single dose.

Why Some Medications Are on the Flush List

The FDA doesn’t make this list lightly. It’s based on real deaths. Between 2010 and 2022, 217 children were accidentally exposed to fentanyl patches - 9 of them died. These aren’t hypothetical risks. A used patch stuck to a playground slide, left in a diaper bag, or sitting on a nightstand can be deadly. The same goes for opioids like methadone, morphine, and oxymorphone. A single pill can stop someone’s breathing.

The EPA and FDA agree: the best way to dispose of any medication is through a drug take-back program. But if you live in a rural area with no nearby collection site, or if you’re cleaning out a medicine cabinet after a loved one’s death and can’t wait for the next National Take Back Day, flushing becomes the only way to prevent tragedy.

The FDA Flush List: What’s Included (2024 Update)

The current FDA Flush List includes only medications with active ingredients that pose an immediate, life-threatening risk if misused. Here’s the full list as of April 2024:

• Buprenorphine - found in BELBUCA, BUAVAIL, BUTRANS, SUBOXONE, SUBUTEX, ZUBSOLV
• Fentanyl - ABSTRAL, ACTIQ, DURAGESIC patches, FENTORA, ONSOLIS
• Hydromorphone - EXALGO extended-release tablets
• Meperidine - DEMEROL
• Methadone - DOLOPHINE, METHADOSE
• Morphine - ARYMO ER, AVINZA, EMBEDA, KADIAN, MORPHABOND ER, MS CONTIN, ORAMPH SR
• Oxymorphone - OPANA, OPANA ER
• Tapentadol - NUCYNTA, NUCYNTA ER
• Sodium oxybate - XYREM, XYWAV
• Diazepam rectal gel - DIASTAT, DIASTAT ACUDIAL
• Methylphenidate transdermal system - DAYTRANA

Notice something? These are all powerful, tightly controlled substances. No antibiotics, no blood pressure pills, no antidepressants. If your medicine isn’t on this list, don’t flush it. Ever.

How to Flush Safely - Step by Step

Flushing isn’t just about dumping pills in the toilet. There’s a correct way to do it - especially for patches and liquids.

1. Check the label. Look for the FDA Flush List logo or the words “Do not flush unless instructed.” If it’s not on the list, skip this step.
2. Check for take-back options. Visit DEA’s Take Back website or call your local pharmacy. National Take Back Day happens twice a year (April and October), but many pharmacies accept meds year-round.
3. Only flush if you have no other choice. If you can’t find a drop-off location within 24 hours, proceed.
4. For pills and capsules: Remove them from the bottle, flush them one at a time. Don’t wait until the bottle is full.
5. For fentanyl or buprenorphine patches: Fold the patch in half, sticky side to sticky side. Then flush it. This prevents accidental skin contact.
6. For liquids: Pour the liquid down the toilet, then flush. Do not pour into a sink.
7. Remove personal info. Scratch out your name and prescription number on the empty bottle before tossing it in the trash.

One common mistake? People flush leftover antibiotics or ibuprofen because they’re “not sure what to do.” That’s wrong. Those drugs belong in the trash - not the toilet.

What About the Environment?

You’ve probably heard that flushing meds harms fish and water supplies. That’s true - but the FDA weighed the risks. Their 2021 environmental review found that the risk of a child dying from a single fentanyl patch is 1,000 times higher than the environmental impact of flushing it.

The U.S. Geological Survey did find traces of 8 Flush List medications in 23% of tested streams. But concentrations were thousands of times lower than what’s needed to affect human health or aquatic life. The FDA says: Don’t flush because it’s safe for the environment. Flush because it saves lives.

What You Should NEVER Flush

These common medications are NOT on the FDA Flush List. Never flush them:

• Antibiotics (amoxicillin, azithromycin)
• Antihistamines (loratadine, cetirizine)
• NSAIDs (ibuprofen, naproxen)
• Antidepressants (sertraline, fluoxetine)
• Diabetes meds (metformin, insulin)
• Thyroid pills (levothyroxine)

For these, the FDA recommends mixing them with an unpalatable substance - like coffee grounds, cat litter, or dirt - in a sealed plastic bag, then throwing them in the trash. This makes them unappealing to kids, pets, or scavengers.

Take-Back Programs Are Still Best - Here’s How to Find One

The DEA runs over 12,000 permanent collection sites across the U.S. And they’re growing. Thanks to the Bipartisan Infrastructure Law, collection sites increased 37% between 2021 and 2023.

To find one near you:

• Go to DEA’s Take Back Locator
• Search by ZIP code
• Look for pharmacies, hospitals, or police stations with a drop-off bin
• Check your state’s health department website - many run year-round programs

Even if you live in a rural area, you’re likely within 50 miles of a drop-off site. If not, ask your pharmacist. Many will mail you a prepaid disposal envelope.

What’s Changing in 2025?

The FDA is actively reviewing the Flush List. In 2023, 17 cases of accidental buprenorphine exposure led them to consider adding new transdermal forms. But they’re also looking at removing some drugs. Three medications on the list may be removed by 2025 because newer versions have abuse-deterrent features - like coatings that turn gel-like if crushed - making them safer to throw away.

By 2025, you’ll likely see clearer disposal instructions on every prescription bottle. The FDA is pushing for standardized labels that say: “Take to a drug collection site. Flush only if no site is available.”

What Happens If You Flush the Wrong Medicine?

Flushing non-Flush List drugs won’t kill anyone - but it’s still wrong. It adds to water pollution, and if enough people do it, regulators may tighten rules on all disposal methods. That could make take-back programs harder to fund.

The real danger? Confusion. If people think “flushing is okay,” they’ll flush everything. And that’s how we end up with more contaminated water and fewer safe disposal options.

Final Rule: Flush Only When You Must

The FDA’s Flush List isn’t a suggestion - it’s a lifesaving tool. But it’s meant for emergencies, not convenience. If you can drop off your meds, do it. If you can’t, and your medicine is on the list, flush it. If you’re unsure, call your pharmacist. One phone call could prevent a child’s death.